PYRIDO[2,3-B]PYRIDINE
Naphthyridine
CAS: 254-60-4
Molecular Formula: C8H6N2
PYRIDO[2,3-B]PYRIDINE - Names and Identifiers
| Name | Naphthyridine |
| Synonyms | Naphthyridine 1,8-NAPHTHYRIDINE 1,8-naphthyridine 1,8-Pyridopyridine 1,8-Diazanapthalene 1,8-DIAZANAPHTHALENE PYRIDO[2,3-B]PYRIDINE 1,8-Naphthyridine(6CI,7CI,8CI,9CI) 1,8-DiazanaphthalenePyrido[2,3-b]pyridine |
| CAS | 254-60-4 |
| InChI | InChI=1/C8H6N2/c1-3-7-4-2-6-10-8(7)9-5-1/h1-6H |
| InChIKey | FLBAYUMRQUHISI-UHFFFAOYSA-N |
PYRIDO[2,3-B]PYRIDINE - Physico-chemical Properties
| Molecular Formula | C8H6N2 |
| Molar Mass | 130.15 |
| Density | 1.183±0.06 g/cm3(Predicted) |
| Melting Point | 99.8-99.9°C |
| Boling Point | 248.9±13.0 °C(Predicted) |
| Flash Point | 107.8°C |
| Solubility | Soluble in methanol, and water (slightly). |
| Vapor Presure | 0.0374mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Light yellow to Light orange |
| pKa | 3.39 |
| Storage Condition | Sealed in dry,Room Temperature |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.653 |
| MDL | MFCD00059751 |
PYRIDO[2,3-B]PYRIDINE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Hazard Class | IRRITANT |
PYRIDO[2,3-B]PYRIDINE - Introduction
Naphthyridine(Naphthyridine) is an organic compound with the chemical formula C8H7N. It is a ring structure composed of two pyridine rings arranged vertically.
Naphthyridine has the following properties:
1. Appearance: Naphthyridine is a white crystalline solid.
2. Solubility: It is soluble in common organic solvents, such as ethanol, dichloromethane and benzene.
3. Reactivity: Naphthyridine is a basic substance that can react with acids or acidic compounds to form salts.
Naphthyridine uses:
1. Chemical synthesis: It can be used as an intermediate in organic synthesis and can participate in the reaction of constructing complex organic molecules.
2. Drug research and development: Due to its special structure and chemical properties, Naphthyridine and its derivatives are often used as the skeleton of drug molecules in drug research and development.
Preparation method of Naphthyridine:
1. Waste Utilization method: It is obtained by heating and reducing the waste methoxy phenyl methyl ether of benzyl alcohol under nitrogen atmosphere.
2. Diazo compound method: the diazo compound is prepared by the reaction of benzaldehyde and sodium hydrocyanate, and then Naphthyridine is obtained by reduction.
Naphthyridine safety information:
Naphthyridine currently has no clear toxicity data, but as an organic compound, it should pay attention to the following safety operations:
1. Avoid inhalation and Contact: avoid contact with Naphthyridine powder or solution to the skin, mouth or eyes, avoid inhalation of its vapor.
2. The use of personal protective equipment: in the laboratory operation, should wear chemical protective glasses, gloves and laboratory coat.
3. Appropriate storage and disposal: Naphthyridine should be stored in a dry, cool place, avoid contact with oxygen, fire and other sources. When disposing of waste, it should be disposed of in accordance with local regulations.
Naphthyridine has the following properties:
1. Appearance: Naphthyridine is a white crystalline solid.
2. Solubility: It is soluble in common organic solvents, such as ethanol, dichloromethane and benzene.
3. Reactivity: Naphthyridine is a basic substance that can react with acids or acidic compounds to form salts.
Naphthyridine uses:
1. Chemical synthesis: It can be used as an intermediate in organic synthesis and can participate in the reaction of constructing complex organic molecules.
2. Drug research and development: Due to its special structure and chemical properties, Naphthyridine and its derivatives are often used as the skeleton of drug molecules in drug research and development.
Preparation method of Naphthyridine:
1. Waste Utilization method: It is obtained by heating and reducing the waste methoxy phenyl methyl ether of benzyl alcohol under nitrogen atmosphere.
2. Diazo compound method: the diazo compound is prepared by the reaction of benzaldehyde and sodium hydrocyanate, and then Naphthyridine is obtained by reduction.
Naphthyridine safety information:
Naphthyridine currently has no clear toxicity data, but as an organic compound, it should pay attention to the following safety operations:
1. Avoid inhalation and Contact: avoid contact with Naphthyridine powder or solution to the skin, mouth or eyes, avoid inhalation of its vapor.
2. The use of personal protective equipment: in the laboratory operation, should wear chemical protective glasses, gloves and laboratory coat.
3. Appropriate storage and disposal: Naphthyridine should be stored in a dry, cool place, avoid contact with oxygen, fire and other sources. When disposing of waste, it should be disposed of in accordance with local regulations.
Last Update：2024-04-09 02:00:44
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